Negamycin ( Negamycin )

Catalog No. M14133 CAS No. 33404-78-3

A dipeptide antibiotic that inhibits the initiation of protein synthesis; also restores dystrophin expression in skeletal and cardiac muscles of the mdx mouse.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Negamycin
Note

Research use only, not for human use.
Brief Description

A dipeptide antibiotic that inhibits the initiation of protein synthesis; also restores dystrophin expression in skeletal and cardiac muscles of the mdx mouse.
Description

A dipeptide antibiotic that inhibits the initiation of protein synthesis; also restores dystrophin expression in skeletal and cardiac muscles of the mdx mouse; interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.
Synonyms

Negamycin
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

33404-78-3
Formula Weight

248.28
Molecular Formula

C9H20N4O4
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)CN(C)NC(C[C@H](N)C[C@@H](O)CN)=O
Chemical Name

N-((3R,5R)-3,6-diamino-5-hydroxyhexanamido)-N-methylglycine

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Arakawa M, et al. J Biochem. 2003 Nov;134(5):751-8.
2. Polikanov YS, et al. Mol Cell. 2014 Nov 20;56(4):541-50.
3. Cocozaki AI, et al. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8188-93.

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