Necroptosis-IN-3

CAS No. 547698-18-0

Necroptosis-IN-3( —— )

Catalog No. M35795 CAS No. 547698-18-0

Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 55 In Stock
10MG 98 In Stock
25MG 191 In Stock
50MG 297 In Stock
100MG 420 In Stock
200MG 583 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Necroptosis-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.
  • Description
    Necroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.
  • In Vitro
    Cell Viability Assay Cell Line:Fadd-/- Jurkat and L929 cells, treated with 10 ng/mL of human TNF-α Concentration:0.030-100 μM Incubation Time:24 h Result:Showed necroptosis inhibitory activity with an ED50 of 7.724 μM for Fadd-/- Jurkat cells and was inactive for L929 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Necroptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    547698-18-0
  • Formula Weight
    223.33
  • Molecular Formula
    C12H17NOS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (447.77 mM; Ultrasonic )
  • SMILES
    C(NCC1=CC=CS1)(=O)C2CCCCC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Junying Yuan, et al. Small molecule inhibitors of necroptosis. Patent US20120122889A1.
molnova catalog
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