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Necroptosis-IN-3
CAS No. 547698-18-0
Necroptosis-IN-3( —— )
Catalog No. M35795 CAS No. 547698-18-0
Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | In Stock |
|
| 10MG | 98 | In Stock |
|
| 25MG | 191 | In Stock |
|
| 50MG | 297 | In Stock |
|
| 100MG | 420 | In Stock |
|
| 200MG | 583 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNecroptosis-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionNecroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.
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DescriptionNecroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.
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In VitroCell Viability Assay Cell Line:Fadd-/- Jurkat and L929 cells, treated with 10 ng/mL of human TNF-α Concentration:0.030-100 μM Incubation Time:24 h Result:Showed necroptosis inhibitory activity with an ED50 of 7.724 μM for Fadd-/- Jurkat cells and was inactive for L929 cells.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorNecroptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number547698-18-0
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Formula Weight223.33
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Molecular FormulaC12H17NOS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (447.77 mM; Ultrasonic )
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SMILESC(NCC1=CC=CS1)(=O)C2CCCCC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Junying Yuan, et al. Small molecule inhibitors of necroptosis. Patent US20120122889A1.
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