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Nabumetone
CAS No. 42924-53-8
Nabumetone( BRL 14777 )
Catalog No. M14456 CAS No. 42924-53-8
Nabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | 41 | In Stock |
|
| 1G | 48 | In Stock |
|
Biological Information
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Product NameNabumetone
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NoteResearch use only, not for human use.
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Brief DescriptionNabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
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DescriptionNabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.(In Vitro):Nabumetone is a potent and selective COX-2 inhibitor. Nabumetone (50 μmol-2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression. (In Vivo):Nabumetone (79 mg/kg, p.o.) inhibits paw oedema and paw exudate PGE2 in rats. Nabumetone does not induce gastric damage and causes only 57% inhibition of gastric mucosal 6-keto-PGF1α production in rats. Nabumetone (25, 50, 100 mg/kg, i.p.) dose-dependently inhibits the increase of DDC-induced mucus secretion and stimulates stress-induced mucus secretion in rats. Nabumetone (25 mg/kg, i.p.) significantly suppresses stress-induced ulcer index in rats.
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In VitroNabumetone is a potent and selective COX-2 inhibitor. Nabumetone (50 μmol-2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression.
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In VivoNabumetone (79 mg/kg, p.o.) inhibits paw oedema and paw exudate PGE2 in rats. Nabumetone does not induce gastric damage and causes only 57% inhibition of gastric mucosal 6-keto-PGF1α production in rats. Nabumetone (25, 50, 100 mg/kg, i.p.) dose-dependently inhibits the increase of DDC-induced mucus secretion and stimulates stress-induced mucus secretion in rats. Nabumetone (25 mg/kg, i.p.) significantly suppresses stress-induced ulcer index in rats.
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SynonymsBRL 14777
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX-1| COX-2| MPO
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number42924-53-8
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Formula Weight228.29
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Molecular FormulaC15H16O2
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Purity>98% (HPLC)
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SolubilityEthanol: 25 mg/mL (109.5 mM); DMSO: 46 mg/mL (201.49 mM)
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SMILESCC(CCC1=CC=C2C=C(OC)C=CC2=C1)=O
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Chemical Name4-(6-methoxynaphthalen-2-yl)butan-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hedner T, et al. Drugs, 2004, 64(20), 2315-2343.
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