NXL101( NXL 101 )

Catalog No. M16502 CAS No. 904302-98-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

NXL101
Note

Research use only, not for human use.
Brief Description

NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria.
Description

NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains; inhibits S. aureus DNA gyrase and topoisomerase IV with IC50 of 1.0 and 18 uM, respectively.Bacterial Infection Phase 1 Discontinued.
In Vitro

——
In Vivo

——
Synonyms

NXL 101
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

Infection
Indication

Bacterial Infection

CAS Number

904302-98-3
Formula Weight

504.635
Molecular Formula

C25H29FN2O4S2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C([C@H]1CN(CCSC2=CC=CS2)CC[C@H]1CC[C@@H](C3=C(F)C=NC4=CC=C(OC)C=C34)O)O
Chemical Name

(3R,4R)-4-[(3S)-3-(3-Fluoro-6-methoxy-4-quinolinyl)-3-hydroxypropyl]-1-[2-(2-thienylthio)ethyl]-3-piperidinecarboxylic acid

1. Black MT, et al. Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49.

Calculator

molnova catalog