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NVP-AEW541
CAS No. 475489-16-8
NVP-AEW541 ( AEW-541;AEW541;AEW 541;NVP AEW541 )
Catalog No. M14585 CAS No. 475489-16-8
NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 257 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNVP-AEW541
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NoteResearch use only, not for human use.
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Brief DescriptionNVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.
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DescriptionNVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM; shows weak activity for closely related InsR (IC50=2.3 uM); inhibits IGF-IR autophosphorylation and abrogates IGF-I-mediated survival and colony formation in soft agar; inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas in vivo; orally bioavailable.Blood Cancer Phase 1 Clinical
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SynonymsAEW-541;AEW541;AEW 541;NVP AEW541
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PathwayAngiogenesis
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TargetIGF-1R
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RecptorFLT1;FLT3;IGF-1R;InsulinReceptor;Tek
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number475489-16-8
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Formula Weight439.55
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Molecular FormulaC27H29N5O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 51 mg/mL
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SMILESNC1=C2C(N([C@H]3C[C@@H](CN4CCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
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Chemical Name7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. García-Echeverría C, et al. Cancer Cell. 2004 Mar;5(3):231-9.
2. Scotlandi K, et al. Cancer Res. 2005 May 1;65(9):3868-76.
3. Tanno B, et al. Clin Cancer Res. 2006 Nov 15;12(22):6772-80.
2. Scotlandi K, et al. Cancer Res. 2005 May 1;65(9):3868-76.
3. Tanno B, et al. Clin Cancer Res. 2006 Nov 15;12(22):6772-80.
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