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NVP-AEW541

CAS No. 475489-16-8

NVP-AEW541 ( AEW-541;AEW541;AEW 541;NVP AEW541 )

Catalog No. M14585 CAS No. 475489-16-8

NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NVP-AEW541
  • Note
    Research use only, not for human use.
  • Brief Description
    NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.
  • Description
    NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM; shows weak activity for closely related InsR (IC50=2.3 uM); inhibits IGF-IR autophosphorylation and abrogates IGF-I-mediated survival and colony formation in soft agar; inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas in vivo; orally bioavailable.Blood Cancer Phase 1 Clinical
  • Synonyms
    AEW-541;AEW541;AEW 541;NVP AEW541
  • Pathway
    Angiogenesis
  • Target
    IGF-1R
  • Recptor
    FLT1;FLT3;IGF-1R;InsulinReceptor;Tek
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    475489-16-8
  • Formula Weight
    439.55
  • Molecular Formula
    C27H29N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 51 mg/mL
  • SMILES
    NC1=C2C(N([C@H]3C[C@@H](CN4CCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
  • Chemical Name
    7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. García-Echeverría C, et al. Cancer Cell. 2004 Mar;5(3):231-9.
2. Scotlandi K, et al. Cancer Res. 2005 May 1;65(9):3868-76.
3. Tanno B, et al. Clin Cancer Res. 2006 Nov 15;12(22):6772-80.
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