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NU6140
CAS No. 444723-13-1
NU6140( —— )
Catalog No. M24404 CAS No. 444723-13-1
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 295 | In Stock |
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| 50MG | 475 | In Stock |
|
| 100MG | 692 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNU6140
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NoteResearch use only, not for human use.
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Brief DescriptionNU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).
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DescriptionNU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
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In VitroNU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H, with IC50s of 6.6, 5.5, 15 and 3.9 μM, respectively.NU6140 increases catalytic activity of capase-9 and capase-3, causes increase in the sub-G1 apoptotic cell population.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAurora Kinase
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RecptorAurora A|Aurora B|CDK1/CyclinB|cdk2/cyclinA|CDK4/CyclinD|cdk5/p25|cdk7/cyclinH
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Research Area——
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Indication——
Chemical Information
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CAS Number444723-13-1
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Formula Weight422.52
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Molecular FormulaC23H30N6O2
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (591.69 mM; Need ultrasonic)
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SMILESCCN(CC)C(C(C=C1)=CC=C1NC2=NC(OCC3CCCCC3)=C4C(N=CN4)=N2)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pennati M, et al. Potentiation of apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37.
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