NSP-805
CAS No. 125068-54-4
NSP-805 ( —— )
Catalog No. M26344 CAS No. 125068-54-4
NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 106 | Get Quote |
|
5MG | 177 | Get Quote |
|
10MG | 303 | Get Quote |
|
25MG | 515 | Get Quote |
|
50MG | 736 | Get Quote |
|
100MG | 1017 | Get Quote |
|
500MG | 2052 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNSP-805
-
NoteResearch use only, not for human use.
-
Brief DescriptionNSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.
-
DescriptionNSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.(In Vitro):In isolated guinea pig left atria, the positive inotropic EC50 values (microM) in order of potency were about 0.18 (NSP-805), 0.39 (indolidan), 1.1 (MCI-154), 1.7 (NSP-804, milrinone), 2.0 (denopamine), 4.0 (papaverine), 4.4 3-isobutyl-1-methylxanthine, IBMX, 6.5 (imazodan), and 27 (amrinone).(In Vivo):In anesthetized dogs, intravenous (i.v.) injection of NSP-804 and NSP-805 produced dose-dependent increases in left ventricular VVdp/dtmax and decreases in aortic blood pressure (ABP) with relatively small increases in heart rate (HR).?The ED50 values (micrograms/kg) for LVdP/dtmax of NSP-804, NSP-805, denopamine, milrinone, MCI-154, and indolidan were 15, 12, 22, 23, 15, and 7.3, respectively.?When the drugs were administered intraduodenally to anesthetized dogs, the ED50 values (micrograms/kg) for LVdP/dtmax of NSP-804, NSP-805, milrinone and indolidan were approximately 30, 10, 200, and 25 respectively.?In the propranolol-induced heart failure model, NSP-804 and NSP-805 completely improved the hemodynamic state of heart failure to normal levels.?The in vitro positive inotropic effects of NSP-804 and NSP-805 were accompanied by increases in tissue cyclic AMP and abolished by carbachol.?NSP-805 was the most potent and selective inhibitor of guinea pig cardiac phosphodiesterase (PDE) III among the agents examined, and NSP-804 was a potent and selective inhibitor of PDE III similar to indolidan.
-
Synonyms——
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorAChE
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number125068-54-4
-
Formula Weight297.4
-
Molecular FormulaC17H19N3O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC1CC(=O)NN=C1c1ccc(NC2=C(C)C(=O)CC2)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Dung HV, et al. Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity. Arch Pharm Res. 2015;38(5):677-82.
molnova catalog
related products
-
ICI 63197
ICI 63197 is a PDE4 inhibitor.
-
Chelerythrine
Chelerythrine is a well-known protein kinase C inhibitor.
-
Arofylline
Arofylline is a PDE4 inhibitor and can be used for asthma studies.