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NSC-87877

CAS No. 56990-57-9

NSC-87877 ( —— )

Catalog No. M22693 CAS No. 56990-57-9

NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).

Purity : >98% (HPLC)

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Biological Information

Product Name

NSC-87877
Note

Research use only, not for human use.
Brief Description

NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).
Description

NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Phosphatase
Recptor

SHP-2;SHP-1;DUSP26
Research Area

——
Indication

——

Chemical Information

CAS Number

56990-57-9
Formula Weight

459.45
Molecular Formula

C19H13N3O7S2
Purity

>98% (HPLC)
Solubility

DMSO:4 mg/mL(8.71 mM)
SMILES

Oc1c(cc(c2cccnc12)S(O)(=O)=O)\N=N\c1ccc2cc(ccc2c1)S(O)(=O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70.

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