NS6180 ( NS6180; NS-6180; NS 6180 )

Catalog No. M14204 CAS No. 353262-04-1

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Datasheet

HNMR

HPLC

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Product Name

NS6180
Note

Research use only, not for human use.
Brief Description

NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation.
Description

NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation.
Synonyms

NS6180; NS-6180; NS 6180
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

KCa3.1 channel
Research Area

Inflammation/Immunology
Indication

——

CAS Number

353262-04-1
Formula Weight

323.33
Molecular Formula

C16H12F3NOS
Purity

>98%(HPLC)
Solubility

DMSO: 100 mM
SMILES

O=C1CSC2=CC=CC=C2N1CC3=CC=CC(C(F)(F)F)=C3
Chemical Name

4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one

1. Strobak D, et al. Br J Pharmacol. 2013 Jan;168(2):432-44.

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