NRX-252262 ( —— )

Catalog No. M24123 CAS No. 2438637-61-5

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

NRX-252262
Note

Research use only, not for human use.
Brief Description

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
Description

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

SCF(β-TrCP)-E3 ligase
Research Area

——
Indication

——

Chemical Information

CAS Number

2438637-61-5
Formula Weight

545.4
Molecular Formula

C23H17Cl2F3N2O4S
Purity

>98% (HPLC)
Solubility

DMSO:8 mg/mL?(14.67 mM;?Need ultrasonic)
SMILES

O=C1C(C(N2CC3=C(C=C(OC)C(OC)=C3)C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.

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