NPS-1034 ( NPS1034; NPS-1034; NPS 1034 )

Catalog No. M17202 CAS No. 1221713-92-3

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Datasheet

HNMR

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Product Name

NPS-1034
Note

Research use only, not for human use.
Brief Description

NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
Description

NPS-1034 is a novel MET inhibitor, which inhibits the activated MET receptor and its constitutively active mutants. NPS-1034, inhibits various constitutively active mutant forms of MET as well as HGF-activated wild-type MET. NPS-1034 inhibited the proliferation of cells expressing activated MET and promoted the regression of tumors formed from such cells in a mouse xenograft model through anti-angiogenic and pro-apoptotic actions. NPS-1034 also inhibited HGF-stimulated activation of MET signaling in the presence or absence of serum. Notably, NPS-1034 inhibited three MET variants that are resistant to the MET inhibitors SU11274, NVP-BVU972, and PHA665752.
Synonyms

NPS1034; NPS-1034; NPS 1034
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

Met; AXL
Research Area

Others-Field
Indication

——

CAS Number

1221713-92-3
Formula Weight

551.54
Molecular Formula

C31H23F2N5O3
Purity

98%
Solubility

DMSO : 34 mg/mL. 61.65 mM;
SMILES

CN1N(C(=O)C(C(=O)NC2=CC=C(OC3=CC=NC4=C3C(=CN4)C3=CC=CC=C3)C(F)=C2)=C1C)C1=CC=C(F)C=C1
Chemical Name

N-(3-fluoro-4-((3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide.