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NP10679
CAS No. 2914889-88-4
NP10679( —— )
Catalog No. M36528 CAS No. 2914889-88-4
NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 445 | Get Quote |
|
| 5MG | 686 | Get Quote |
|
| 10MG | 938 | Get Quote |
|
| 25MG | 1398 | Get Quote |
|
| 50MG | 1822 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNP10679
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NoteResearch use only, not for human use.
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Brief DescriptionNP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.
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DescriptionNP10679 is a selective, pH dependent GluN2B subunit-specific N-methyl-D-aspartate (NMDA) receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC50s of 23 and 142 nM at pH 6.9 and 7.6, respectively. NP10679 is a histamine H1 antagonist and a hERG channel inhibitor with IC50s of 73 and 620 nM, respectively. NP10679 is a reversible inhibitor of human liver CYP enzymes.
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In Vitro——
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In VivoAnimal Model:Male C57BL/6 middle cerebral artery occlusion (MCAo) model of transient ischemia mice Dosage:2, 5 and 10 mg/kg Administration:Intraperitoneal injection; 2, 5 and 10 mg/kg, 15 minutes prior to transient ischemia Result:Dose-dependently reduced infarct volumes with an ED50 of 1 mg/kg.
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Synonyms——
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PathwayAngiogenesis
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TargetHER/HSP
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RecptorHER | P450 | Histamine Receptor | NMDAR
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Research Area——
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Indication——
Chemical Information
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CAS Number2914889-88-4
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Formula Weight449.47
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Molecular FormulaC23H26F3N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (222.48 mM; Ultrasonic )
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SMILESO(C[C@@H](CN1CCN(CC1)C2=CC=C(C(F)(F)F)C=C2)O)C=3C=C4C(=CC3)NC(=O)CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zaczek R, et al. Phase 1 Clinical Results for NP10679, a pH-sensitive GluN2B-selective N-methyl-d-aspartate Receptor Inhibitor. Clin Pharmacol Drug Dev. 2023 Jan 15.?
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