NMS-P937

CAS No. 1034616-18-6

NMS-P937 ( PCM-075; PCM 075;NMS1286937 )

Catalog No. M17767 CAS No. 1034616-18-6

NMS-P937 (NMS1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 35 In Stock
5MG 58 In Stock
10MG 80 In Stock
25MG 138 In Stock
50MG 215 In Stock
100MG 356 In Stock
200MG 460 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    NMS-P937
  • Note
    Research use only, not for human use.
  • Brief Description
    NMS-P937 (NMS1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.
  • Description
    Onvansertib, also know as NMS-P937, PCM-075 and NMS1286937, is a n orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.
  • Synonyms
    PCM-075; PCM 075;NMS1286937
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PLK1; PLK2; PLK3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1034616-18-6
  • Formula Weight
    532.52
  • Molecular Formula
    C24H27F3N8O3
  • Purity
    98%
  • Solubility
    DMSO : 21 mg/mL. 39.44 mM;
  • SMILES
    CN1CCN(CC1)c1cc(c(cc1)OC(F)(F)F)Nc1ncc2CCc3c(c2n1)n(nc3C(=O)N)CCO
  • Chemical Name
    1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Beria I, et al. Bioorg Med Chem Lett. 2011, 21(10), 2969-2974.
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