NMS-P937
CAS No. 1034616-18-6
NMS-P937 ( PCM-075; PCM 075;NMS1286937 )
Catalog No. M17767 CAS No. 1034616-18-6
NMS-P937 (NMS1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 35 | In Stock |
|
5MG | 58 | In Stock |
|
10MG | 80 | In Stock |
|
25MG | 138 | In Stock |
|
50MG | 215 | In Stock |
|
100MG | 356 | In Stock |
|
200MG | 460 | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNMS-P937
-
NoteResearch use only, not for human use.
-
Brief DescriptionNMS-P937 (NMS1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.
-
DescriptionOnvansertib, also know as NMS-P937, PCM-075 and NMS1286937, is a n orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.
-
SynonymsPCM-075; PCM 075;NMS1286937
-
PathwayOthers
-
TargetOther Targets
-
RecptorPLK1; PLK2; PLK3
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1034616-18-6
-
Formula Weight532.52
-
Molecular FormulaC24H27F3N8O3
-
Purity98%
-
SolubilityDMSO : 21 mg/mL. 39.44 mM;
-
SMILESCN1CCN(CC1)c1cc(c(cc1)OC(F)(F)F)Nc1ncc2CCc3c(c2n1)n(nc3C(=O)N)CCO
-
Chemical Name1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Beria I, et al. Bioorg Med Chem Lett. 2011, 21(10), 2969-2974.
molnova catalog
related products
-
Deacetyl ganoderic a...
Deacetyl ganoderic acid F is a natural product from Ganoderma lucidum.
-
Decursin
Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug.
-
Solanidine
Solanidine is a cholestane alkaloid isolated from several potato species. It can inhibit proliferation and exhibit obvious antitumor effect.