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NMS-P937
CAS No. 1034616-18-6
NMS-P937 ( PCM-075; PCM 075;NMS1286937 )
Catalog No. M17767 CAS No. 1034616-18-6
NMS-P937 (NMS1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 35 | In Stock |
|
| 5MG | 58 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 138 | In Stock |
|
| 50MG | 215 | In Stock |
|
| 100MG | 356 | In Stock |
|
| 200MG | 460 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNMS-P937
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NoteResearch use only, not for human use.
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Brief DescriptionNMS-P937 (NMS1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.
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DescriptionOnvansertib, also know as NMS-P937, PCM-075 and NMS1286937, is a n orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.
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SynonymsPCM-075; PCM 075;NMS1286937
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PathwayOthers
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TargetOther Targets
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RecptorPLK1; PLK2; PLK3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1034616-18-6
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Formula Weight532.52
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Molecular FormulaC24H27F3N8O3
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Purity98%
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SolubilityDMSO : 21 mg/mL. 39.44 mM;
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SMILESCN1CCN(CC1)c1cc(c(cc1)OC(F)(F)F)Nc1ncc2CCc3c(c2n1)n(nc3C(=O)N)CCO
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Chemical Name1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beria I, et al. Bioorg Med Chem Lett. 2011, 21(10), 2969-2974.
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