Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - PARP - NMS-P118

NMS-P118

CAS No. 1262417-51-5

NMS-P118( NMS-P118 | NMS-P 118 | NMS P118 )

Catalog No. M11093 CAS No. 1262417-51-5

A potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 60 Get Quote
5MG 105 Get Quote
10MG 177 Get Quote
25MG 357 Get Quote
50MG 537 Get Quote
100MG 781 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    NMS-P118
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.
  • Description
    A potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2; exhibits excellent ADME and pharmacokinetic profiles and high efficacy in MDA-MB-436 and Capan-1 xenograft models; orally available.Breast Cancer Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NMS-P118 | NMS-P 118 | NMS P118
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    1262417-51-5
  • Formula Weight
    395.4187
  • Molecular Formula
    C20H24F3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 16 mg/mL
  • SMILES
    O=C(C1=CC(F)=CC(CN2C3CCN(C4CCC(F)(F)CC4)CC3)=C1C2=O)N
  • Chemical Name
    1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Papeo G, et al. J Med Chem. 2015 Sep 10;58(17):6875-98.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Amelparib hydrochlor...

    Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.

  • OUL35

    OUL35 is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.

  • Pamiparib

    Pamiparib (BGB-290, BGB290) is a?highly potent, selective and brain penetrant PARP1/2 inhibitor with potent anti-tumor activity.

Sign In Join Free