NMS-859
CAS No. 1449236-96-7
NMS-859 ( ZINC169324353 )
Catalog No. M26335 CAS No. 1449236-96-7
NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 204 | Get Quote |
|
5MG | 312 | Get Quote |
|
10MG | 447 | Get Quote |
|
25MG | 714 | Get Quote |
|
50MG | 1017 | Get Quote |
|
100MG | 1368 | Get Quote |
|
500MG | 2673 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNMS-859
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NoteResearch use only, not for human use.
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Brief DescriptionNMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
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DescriptionNMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.(In Vitro):NMS-859 suppresses the cell proliferation with IC50s of 3.0 μM and 3.5 μM in HeLa and HCT116 cell lines, respectively. NMS-859 shows weak inhibitory activity against VCPC522T.
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SynonymsZINC169324353
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PathwayOthers
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TargetOther Targets
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RecptorADC Cytotoxin; Microtubule/Tubulin
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Research Area——
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Indication——
Chemical Information
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CAS Number1449236-96-7
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Formula Weight349.8
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Molecular FormulaC15H12ClN3O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESClCC(=O)Nc1cccc(NC2=NS(=O)(=O)c3ccccc23)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65.
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