NMS-859

CAS No. 1449236-96-7

NMS-859 ( ZINC169324353 )

Catalog No. M26335 CAS No. 1449236-96-7

NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 204 Get Quote
5MG 312 Get Quote
10MG 447 Get Quote
25MG 714 Get Quote
50MG 1017 Get Quote
100MG 1368 Get Quote
500MG 2673 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    NMS-859
  • Note
    Research use only, not for human use.
  • Brief Description
    NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
  • Description
    NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.(In Vitro):NMS-859 suppresses the cell proliferation with IC50s of 3.0 μM and 3.5 μM in HeLa and HCT116 cell lines, respectively. NMS-859 shows weak inhibitory activity against VCPC522T.
  • Synonyms
    ZINC169324353
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ADC Cytotoxin; Microtubule/Tubulin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1449236-96-7
  • Formula Weight
    349.8
  • Molecular Formula
    C15H12ClN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ClCC(=O)Nc1cccc(NC2=NS(=O)(=O)c3ccccc23)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65.
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