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NLRP3-IN-9

CAS No. 88039-46-7

NLRP3-IN-9( NLRP3 IN 9 | NLRP3IN9 | INF-4E | INF 4E | INF4E )

Catalog No. M27905 CAS No. 88039-46-7

NLRP3-IN-9 is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NLRP3-IN-9
  • Note
    Research use only, not for human use.
  • Brief Description
    NLRP3-IN-9 is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
  • Description
    NLRP3-IN-9 is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
  • In Vitro
    INF4E (compound 9) preventes both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
  • In Vivo
    INF4E significantly reduces the in infarct size and lactate dehydrogenase release and improvement in postischemic left ventricular pressure.INF4E attenuates the formation of NLRP3 inflammasome complex was induced by myocardial IR (ischemia/reperfusion) in a time-dependent way.
  • Synonyms
    NLRP3 IN 9 | NLRP3IN9 | INF-4E | INF 4E | INF4E
  • Pathway
    NF-κB
  • Target
    NOD
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    88039-46-7
  • Formula Weight
    240.68
  • Molecular Formula
    C12H13ClO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (415.49 mM)
  • SMILES
    CCOC(=O)C(=C)C(O)c1ccccc1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cooley RB, Sondermann H. Probing Protein-Protein Interactions with Genetically Encoded Photoactivatable Cross-Linkers. Methods Mol Biol. 2017;1657:331-345.
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