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NKP-608

CAS No. 177707-12-9

NKP-608 ( NK 608;NK608 )

Catalog No. M12675 CAS No. 177707-12-9

A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NKP-608
  • Note
    Research use only, not for human use.
  • Brief Description
    A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.
  • Description
    A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM; exhibits an anxiolytic-like effect in the social interaction and social exploration test in rats; orally active.Irritable Bowel Syndrome Discontinued
  • Synonyms
    NK 608;NK608
  • Pathway
    GPCR/G Protein
  • Target
    Neurokinin Receptor
  • Recptor
    Neurokinin Receptor
  • Research Area
    Other Indications
  • Indication
    Irritable Bowel Syndrome

Chemical Information

  • CAS Number
    177707-12-9
  • Formula Weight
    619.98
  • Molecular Formula
    C31H24ClF6N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=CC=NC2=CC=CC=C12)N[C@@H]3C[C@@H](CC4=CC=C(Cl)C=C4)N(C(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)CC3
  • Chemical Name
    4-Quinolinecarboxamide, N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]-4-piperidinyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gentsch C, et al. Behav Brain Res. 2002 Jul 18;133(2):363-8.
2. Vassout A, et al. Regul Pept. 2000 Dec 22;96(1-2):7-16.
3. Coulson FR, et al. Inflamm Res. 2002 Jul;51(7):317-23.
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