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NKP-608
CAS No. 177707-12-9
NKP-608( NK 608 | NK608 )
Catalog No. M12675 CAS No. 177707-12-9
A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 233 | Get Quote |
|
| 50MG | 896 | Get Quote |
|
| 100MG | 1422 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNKP-608
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NoteResearch use only, not for human use.
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Brief DescriptionA non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.
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DescriptionA non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM; exhibits an anxiolytic-like effect in the social interaction and social exploration test in rats; orally active.Irritable Bowel Syndrome Discontinued.
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In Vitro——
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In Vivo——
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SynonymsNK 608 | NK608
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PathwayGPCR/G Protein
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TargetNeurokinin Receptor
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RecptorNeurokinin Receptor
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Research AreaOther Indications
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IndicationIrritable Bowel Syndrome
Chemical Information
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CAS Number177707-12-9
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Formula Weight619.9846
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Molecular FormulaC31H24ClF6N3O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C1=CC=NC2=CC=CC=C12)N[C@@H]3C[C@@H](CC4=CC=C(Cl)C=C4)N(C(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)CC3
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Chemical Name4-Quinolinecarboxamide, N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]-4-piperidinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gentsch C, et al. Behav Brain Res. 2002 Jul 18;133(2):363-8.
2. Vassout A, et al. Regul Pept. 2000 Dec 22;96(1-2):7-16.
3. Coulson FR, et al. Inflamm Res. 2002 Jul;51(7):317-23.
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