
NK150460
CAS No. 709640-62-0
NK150460( NK 150460 | NK-150460 )
Catalog No. M15722 CAS No. 709640-62-0
A potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway.
Purity : >98% (HPLC)






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Biological Information
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Product NameNK150460
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway.
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DescriptionA potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway; inhibits growth of not only most ER-positive, but also some ER-negative breast cancer cell lines, while never inhibiting growth of non-breast cancer cell lines; inhibits 17β-estradiol (E2)-dependent transcription without affecting binding of E2 to ER; does not induce histone H2AX phosphorylation or p53 expression, is a a novel AhR agonist dependent on AhR/ARNT and cytochrome P450 CYP1A1.
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In Vitro——
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In Vivo——
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SynonymsNK 150460 | NK-150460
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PathwayEndocrinology/Hormones
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TargetAhR
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RecptorAhR
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Research Area——
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Indication——
Chemical Information
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CAS Number709640-62-0
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Formula Weight308.304
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Molecular FormulaC16H15F3N2O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(5S,7S)-7-methyl-3-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrocinnolin-5-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fukasawa K, et al. Mol Cancer Ther. 2015 Feb;14(2):343-54.
2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.
molnova catalog



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