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NK150460

CAS No. 709640-62-0

NK150460( NK 150460 | NK-150460 )

Catalog No. M15722 CAS No. 709640-62-0

A potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NK150460
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway.
  • Description
    A potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway; inhibits growth of not only most ER-positive, but also some ER-negative breast cancer cell lines, while never inhibiting growth of non-breast cancer cell lines; inhibits 17β-estradiol (E2)-dependent transcription without affecting binding of E2 to ER; does not induce histone H2AX phosphorylation or p53 expression, is a a novel AhR agonist dependent on AhR/ARNT and cytochrome P450 CYP1A1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NK 150460 | NK-150460
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    709640-62-0
  • Formula Weight
    308.304
  • Molecular Formula
    C16H15F3N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (5S,7S)-7-methyl-3-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrocinnolin-5-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fukasawa K, et al. Mol Cancer Ther. 2015 Feb;14(2):343-54. 2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.
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