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NJK14047
CAS No. 1800576-41-3
NJK14047( NJK 14047 )
Catalog No. M12739 CAS No. 1800576-41-3
NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNJK14047
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NoteResearch use only, not for human use.
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Brief DescriptionNJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α.
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DescriptionNJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation; inhibits RSV- and influenza A-mediated p38 MAPK activation in epithelial cells, decreases viral replication and viral mRNA synthesis; also displays significant anti-HBV activity, efficiently suppresses the secretion of HBV antigens and HBV particles from HBV genome-transfected cells.
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In Vitro——
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In Vivo——
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SynonymsNJK 14047
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38 MAPK
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number1800576-41-3
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Formula Weight445.515
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Molecular FormulaC27H27NO5
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(C=C(C=C1)C(=O)NC2CC2)C3=CC=C(C=C3)C(=O)C4=CC=C(C=C4)OCC(CO)O
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Chemical NameN-cyclopropyl-4'-(4-(2,3-dihydroxypropoxy)benzoyl)-6-methyl-[1,1'-biphenyl]-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kim SY, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00214-17.
2. Choi MS, et al. Biochem Biophys Res Commun. 2016 Aug 26;477(3):311-6.
3. Heo J, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3694-8.
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