NITD-916 ( NITD916 )

Catalog No. M12349 CAS No. 1614262-83-7

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Datasheet

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HPLC

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Product Name

NITD-916
Note

Research use only, not for human use.
Brief Description

NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM.
Description

NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
Synonyms

NITD916
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

1614262-83-7
Formula Weight

311.43
Molecular Formula

C20H25NO2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1(CCC(CC1)CC2=CC(=C(C(=O)N2)C3=CC=CC=C3)O)C
Chemical Name

6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one

1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.
2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136.

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