NCT-503 ( NCT-503; NCT 503; NCT503 )

Catalog No. M18172 CAS No. 1916571-90-8

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Product Name

NCT-503
Note

Research use only, not for human use.
Brief Description

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
Description

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 μM.
Synonyms

NCT-503; NCT 503; NCT503
Pathway

Others
Target

Other Targets
Recptor

PHGDH (Cell-free) ; FLT3; AXL
Research Area

——
Indication

——

CAS Number

1916571-90-8
Formula Weight

408.49
Molecular Formula

C20H23F3N4S
Purity

98%
Solubility

DMSO : 50 mg/mL 122.41 mM;
SMILES

Cc1cc(nc(c1)NC(=S)N1CCN(CC1)Cc1ccc(cc1)C(F)(F)F)C
Chemical Name

N-(4,6-dimethylpyridin-2-yl)-4-(4-(trifluoromethyl)benzyl)piperazine-1-carbothioamide

1. Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8.

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