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NCT-501
CAS No. 1802088-50-1
NCT-501( NCT501 )
Catalog No. M12749 CAS No. 1802088-50-1
NCT-501 (NCT501) is a potent and highly selective inhibitor of ALDH1A1 with IC50 of 40 nM for hALDH1A1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
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| 10MG | 150 | Get Quote |
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| 25MG | 309 | Get Quote |
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| 50MG | 476 | Get Quote |
|
| 100MG | 690 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNCT-501
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NoteResearch use only, not for human use.
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Brief DescriptionNCT-501 (NCT501) is a potent and highly selective inhibitor of ALDH1A1 with IC50 of 40 nM for hALDH1A1.
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DescriptionNCT-501 (NCT501) is a potent and highly selective inhibitor of ALDH1A1 with IC50 of 40 nM for hALDH1A1; exhibits high selectivity against ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2 isozymes and other dehydrogenases such as HPGD and HSD17β4; excellent pharmacokinetics and in vitro ADME profiles.
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In Vitro——
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In VivoAnimal Model:5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells)Dosage:100μg/animal Administration:Intra-tumorally (i.t); every alternate day for 20 days Result:Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.
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SynonymsNCT501
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PathwayMetabolic Enzyme/Protease
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TargetALDH
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RecptorALDH1A1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1802088-50-1
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Formula Weight416.5172
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Molecular FormulaC21H32N6O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 28 mg/mL
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SMILESO=C(C(N(CCC(C)C)C(CN1CCN(C(C2CC2)=O)CC1)=N3)=C3N4C)N(C)C4=O
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Chemical Name1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yang SM, et al. J Med Chem. 2015 Aug 13;58(15):5967-78.
2. Kulsum S, et al. Mol Carcinog. 2017 Feb;56(2):694-711.
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