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Home - Products - Metabolic Enzyme/Protease - ALDH - NCT-501

NCT-501

CAS No. 1802088-50-1

NCT-501( NCT501 )

Catalog No. M12749 CAS No. 1802088-50-1

NCT-501 (NCT501) is a potent and highly selective inhibitor of ALDH1A1 with IC50 of 40 nM for hALDH1A1.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NCT-501
  • Note
    Research use only, not for human use.
  • Brief Description
    NCT-501 (NCT501) is a potent and highly selective inhibitor of ALDH1A1 with IC50 of 40 nM for hALDH1A1.
  • Description
    NCT-501 (NCT501) is a potent and highly selective inhibitor of ALDH1A1 with IC50 of 40 nM for hALDH1A1; exhibits high selectivity against ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2 isozymes and other dehydrogenases such as HPGD and HSD17β4; excellent pharmacokinetics and in vitro ADME profiles.
  • In Vitro
    ——
  • In Vivo
    Animal Model:5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells)Dosage:100μg/animal Administration:Intra-tumorally (i.t); every alternate day for 20 days Result:Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.
  • Synonyms
    NCT501
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    ALDH
  • Recptor
    ALDH1A1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1802088-50-1
  • Formula Weight
    416.5172
  • Molecular Formula
    C21H32N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    O=C(C(N(CCC(C)C)C(CN1CCN(C(C2CC2)=O)CC1)=N3)=C3N4C)N(C)C4=O
  • Chemical Name
    1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yang SM, et al. J Med Chem. 2015 Aug 13;58(15):5967-78. 2. Kulsum S, et al. Mol Carcinog. 2017 Feb;56(2):694-711.
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