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NCB-0846
CAS No. 1792999-26-8
NCB-0846( NCB 0846 | NCB0846 )
Catalog No. M12701 CAS No. 1792999-26-8
The first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 237 | In Stock |
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| 50MG | 402 | In Stock |
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| 100MG | 593 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNCB-0846
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NoteResearch use only, not for human use.
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Brief DescriptionThe first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM.
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DescriptionThe first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM; also weakly inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK (IC80>0.1 uM); induces faster migration of TCF4 phosphorylated by TNIK at 0.1-0.3 uM, and completely inhibits at 3 uM; also reduces the expression of TNIK, AXIN2, cMYC, LRP6 and LRP5; abrogates colorectal cancer stemness, suppresses Wnt-driven intestinal tumorigenesis in Apc(min/+) mice. Colon Cancer Preclinical.
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In Vitro——
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In Vivo——
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SynonymsNCB 0846 | NCB0846
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PathwayWnt/Notch/Hedgehog
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TargetTNIK
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RecptorTNIK
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Research AreaCancer
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IndicationColon Cancer
Chemical Information
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CAS Number1792999-26-8
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Formula Weight375.4237
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Molecular FormulaC21H21N5O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESO[C@H]1CC[C@@H](OC2=CC=CC3=CN=C(NC4=CC=C5N=CNC5=C4)N=C23)CC1
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Chemical NameCyclohexanol, 4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-, cis-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Masuda M, et al. Nat Commun. 2016 Aug 26;7:12586.
2. Yamada T, et al. Cancer Sci. 2017 May;108(5):818-823.
3. Mahmoudi T, et al. EMBO J. 2009 Nov 4;28(21):3329-40.
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