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NC1153

CAS No. 150661-91-9

NC1153( NC-1153 | NC 1153 )

Catalog No. M12100 CAS No. 150661-91-9

A Mannich base compound, selective and orally active JAK3 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NC1153
  • Note
    Research use only, not for human use.
  • Brief Description
    A Mannich base compound, selective and orally active JAK3 inhibitor.
  • Description
    A Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b; fails to inhibit several other enzymes, including growth factor receptor tyrosine kinases, Src family members, and serine/threonine protein kinases; inhibits proliferation of normal human T cells challenged with IL-2, IL-4, or IL-7; significantly extends survival of MHC/non-MHC mismatched rat kidney allografts, induces transplantation tolerance in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NC-1153 | NC 1153
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    150661-91-9
  • Formula Weight
    369.415
  • Molecular Formula
    C18H38Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C(CN(C)C)CCCCCCCCCC1CN(C)C
  • Chemical Name
    2,12-bis((dimethylamino)methyl)cyclododecan-1-one dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stepkowski SM, et al. J Immunol. 2005 Oct 1;175(7):4236-46. 2. Nagy ZS, et al. Mol Cancer. 2009 Aug 26;8:67. 3. Nagy ZS, et al. FEBS Lett. 2010 Apr 16;584(8):1515-20.
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