NBDHEX

Research use only, not for human use.

NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).(In Vitro):NBDHEX not only is cytotoxic toward the parental small cell lung cancer H69 cell line (LC(50) of 2.3 +/- 0.6 micromol/L) but also overcomes the multidrug resistance of its variant, H69AR, which overexpresses the ATP-binding cassette transporter multidrug resistance-associated protein 1 (MRP1;?LC(50) of 4.5 +/- 0.9 micromol/L).?Drug efflux experiments, done in the presence of a specific inhibitor of MRP1, confirmed that NBDHEX is not a substrate for this export pump .(In Vivo):NBDHEX, In female mice, treatment results in a statistically significant tumour inhibition (approximately 70%) .

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Apoptosis

Apoptosis

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787634-60-0

297.3

C12H15N3O4S

>98% (HPLC)

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OCCCCCCSc1ccc([N+]([O-])=O)c2nonc12

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(-20℃)

With Ice Pack

≥ 2 years