NBC19

CAS No. 2068818-75-5

NBC19( NBC 19 )

Catalog No. M13217 CAS No. 2068818-75-5

NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NBC19
  • Note
    Research use only, not for human use.
  • Brief Description
    NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.
  • Description
    NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NBC 19
  • Pathway
    NF-κB
  • Target
    NOD
  • Recptor
    NOD
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2068818-75-5
  • Formula Weight
    491.644
  • Molecular Formula
    C24H26BCl3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    1-(6-(cyclohexylamino)-2,2-diphenyl-4-(trichloromethyl)-2,3-dihydro-1l3,3,2l4-oxazaborinin-5-yl)ethan-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Redondo-Castro E, et al. Sci Rep. 2018 Apr 4;8(1):5667. 2. Baldwin AG, et al. Cell Chem Biol. 2017 Nov 16;24(11):1321-1335.e5.
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