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N-Arachidonylglycine

CAS No. 179113-91-8

N-Arachidonylglycine( —— )

Catalog No. M33893 CAS No. 179113-91-8

N-Arachidonylglycine (NA-Gly) is a heat-dependent circulating metabolite with anti-inflammatory, anticancer, antidiabetic and antioxidant activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    N-Arachidonylglycine
  • Note
    Research use only, not for human use.
  • Brief Description
    N-Arachidonylglycine (NA-Gly) is a heat-dependent circulating metabolite with anti-inflammatory, anticancer, antidiabetic and antioxidant activities.
  • Description
    N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.
  • In Vitro
    N-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells.N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm.Western Blot Analysis Cell Line:HEK293-GPR18 cells Concentration:0.1 nM-100 μM Incubation Time:5 minResult:Drove MAPK activation.
  • In Vivo
    N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold.N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells.Animal Model:Rats Dosage:10 mg/kg Administration:Oral Result:Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid.Animal Model:Mouse (peritonitis model)Dosage:1.2 mg/kg Administration:Oral; once Result:Resulted in a significant 70% reduction of peritoneal cells.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Antioxidant
  • Recptor
    Antioxidant
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    179113-91-8
  • Formula Weight
    361.52
  • Molecular Formula
    C22H35NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (276.61 mM; Ultrasonic (<60°C); )Ethanol : 50 mg/mL (138.30 mM; Ultrasonic)
  • SMILES
    CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCC(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. McHugh D, et al. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012;165(8):2414-2424.?
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