
N-Arachidonylglycine
CAS No. 179113-91-8
N-Arachidonylglycine( —— )
Catalog No. M33893 CAS No. 179113-91-8
N-Arachidonylglycine (NA-Gly) is a heat-dependent circulating metabolite with anti-inflammatory, anticancer, antidiabetic and antioxidant activities.
Purity : >98% (HPLC)






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Biological Information
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Product NameN-Arachidonylglycine
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NoteResearch use only, not for human use.
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Brief DescriptionN-Arachidonylglycine (NA-Gly) is a heat-dependent circulating metabolite with anti-inflammatory, anticancer, antidiabetic and antioxidant activities.
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DescriptionN-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.
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In VitroN-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells.N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm.Western Blot Analysis Cell Line:HEK293-GPR18 cells Concentration:0.1 nM-100 μM Incubation Time:5 minResult:Drove MAPK activation.
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In VivoN-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold.N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells.Animal Model:Rats Dosage:10 mg/kg Administration:Oral Result:Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid.Animal Model:Mouse (peritonitis model)Dosage:1.2 mg/kg Administration:Oral; once Result:Resulted in a significant 70% reduction of peritoneal cells.
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Synonyms——
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PathwayOthers
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TargetAntioxidant
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RecptorAntioxidant
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Research Area——
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Indication——
Chemical Information
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CAS Number179113-91-8
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Formula Weight361.52
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Molecular FormulaC22H35NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (276.61 mM; Ultrasonic (<60°C); )Ethanol : 50 mg/mL (138.30 mM; Ultrasonic)
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SMILESCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCC(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McHugh D, et al. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012;165(8):2414-2424.?
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