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Home - Products - GPCR/G Protein - Antibacterial - N-Acetyl-Calicheamicin

N-Acetyl-Calicheamicin

CAS No. 108212-76-6

N-Acetyl-Calicheamicin ( N-Acetyl-Calicheamicin γ;N-Acetyl-γ-calicheamicin )

Catalog No. M10325 CAS No. 108212-76-6

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic; targets DNA and causes strand scission.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    N-Acetyl-Calicheamicin
  • Note
    Research use only, not for human use.
  • Brief Description
    N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic; targets DNA and causes strand scission.
  • Description
    N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic; targets DNA and causes strand scission; a ADC payload in antibody drug conjugates development.
  • Synonyms
    N-Acetyl-Calicheamicin γ;N-Acetyl-γ-calicheamicin
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    108212-76-6
  • Formula Weight
    1410.39
  • Molecular Formula
    C57H76IN3O22S4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCN(C1COC(CC1OC)OC2C(C(C(OC2OC3C#CC=CC#CC4(CC(=O)C(=C3C4=CCSSSC)NC(=O)OC)O)C)NOC5CC(C(C(O5)C)SC(=O)C6=C(C(=C(C(=C6OC)OC)OC7C(C(C(C(O7)C)O)OC)O)I)C)O)O)C(=O)C
  • Chemical Name
    Carbamic acid, [(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyrano

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stasi R, et al. Cancer Treat Rev. 2008 Feb;34(1):49-60.
2. Naito K, et al. Leukemia. 2000 Aug;14(8):1436-43.
3. Hills RK, et al. Lancet Oncol. 2014 Aug;15(9):986-96.
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