N-Acetyl-Calicheamicin

CAS No. 108212-76-6

N-Acetyl-Calicheamicin ( N-Acetyl-Calicheamicin γ;N-Acetyl-γ-calicheamicin )

Catalog No. M10325 CAS No. 108212-76-6

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic; targets DNA and causes strand scission.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1017 Get Quote
10MG 1368 Get Quote
25MG 2025 Get Quote
50MG 2673 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    N-Acetyl-Calicheamicin
  • Note
    Research use only, not for human use.
  • Brief Description
    N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic; targets DNA and causes strand scission.
  • Description
    N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic; targets DNA and causes strand scission; a ADC payload in antibody drug conjugates development.
  • Synonyms
    N-Acetyl-Calicheamicin γ;N-Acetyl-γ-calicheamicin
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    108212-76-6
  • Formula Weight
    1410.39
  • Molecular Formula
    C57H76IN3O22S4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCN(C1COC(CC1OC)OC2C(C(C(OC2OC3C#CC=CC#CC4(CC(=O)C(=C3C4=CCSSSC)NC(=O)OC)O)C)NOC5CC(C(C(O5)C)SC(=O)C6=C(C(=C(C(=C6OC)OC)OC7C(C(C(C(O7)C)O)OC)O)I)C)O)O)C(=O)C
  • Chemical Name
    Carbamic acid, [(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyrano

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stasi R, et al. Cancer Treat Rev. 2008 Feb;34(1):49-60.
2. Naito K, et al. Leukemia. 2000 Aug;14(8):1436-43.
3. Hills RK, et al. Lancet Oncol. 2014 Aug;15(9):986-96.
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