Mycro-3( Mycro3 | Mycro-3 | Mycro 3 )

Catalog No. M17683 CAS No. 944547-46-0

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Product Name

Mycro-3
Note

Research use only, not for human use.
Brief Description

Mycro 3 is potent and selective for c-Myc in whole cell assays.
Description

Mycro3 is an inhibitor of Myc-Max dimerization.
In Vitro

——
In Vivo

Animal Model:Moribund Pdx1-cre/KRAS* mice bearing pancreatic ductal adenocarcinoma (PDA)Dosage:100 mg/kg Administration:Oral administration; daily for two months Result:Increased survival time.Mycro 3 administration was discontinued after two months, the mouse survived for an additional month.
Synonyms

Mycro3 | Mycro-3 | Mycro 3
Pathway

Others
Target

Other Targets
Recptor

c-Myc
Research Area

——
Indication

——

CAS Number

944547-46-0
Formula Weight

526.88
Molecular Formula

C24H17ClF2N6O4
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL; 189.80 mM
SMILES

CCOC(=O)c1c(n(nc1)c1ccccc1)NC(=O)c1nn2c(cc(nc2c1)c1ccco1)C(F)(F)Cl
Chemical Name

5-[[[7-(Chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester

1.Chen BJ, et al. Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci. 2014 Sep 13;10(10):1084-96.

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