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Motolimod
CAS No. 926927-61-9
Motolimod( VTX-2337 | VTX 2337 | VTX2337 | Motolimod )
Catalog No. M17666 CAS No. 926927-61-9
Motolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 66 | In Stock |
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| 5MG | 110 | In Stock |
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| 10MG | 177 | In Stock |
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| 25MG | 356 | In Stock |
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| 50MG | 533 | In Stock |
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| 100MG | 761 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMotolimod
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NoteResearch use only, not for human use.
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Brief DescriptionMotolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
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DescriptionMotolimod, also known as VTX-2337, is a small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating and antineoplastic activities. TLR8 agonist VTX-2337 binds to TLR8, present in cutaneous dendritic cells, monocytes/macrophages, and mast cells, which may result in the activation of the central transcription factor nuclear factor-B, the secretion of proinflammatory cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response. Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs, recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in the innate immune system.
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In Vitro——
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In Vivo——
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SynonymsVTX-2337 | VTX 2337 | VTX2337 | Motolimod
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PathwayNeuroscience
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TargetGluR
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RecptorTLR8
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number926927-61-9
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Formula Weight458.6
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Molecular FormulaC28H34N4O2
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL. 109.03 mM;
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SMILESCCCN(CCC)C(=O)C1=Cc2c(cc(cc2)c2ccc(cc2)C(=O)N2CCCC2)N=C(N)C1
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Chemical Name2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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ML 254
ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents.
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4-oxo-1,4-dihydroqui...
4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
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Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
