
Mollugin
CAS No. 55481-88-4
Mollugin( Rubimaillin | Mollugin )
Catalog No. M18804 CAS No. 55481-88-4
Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway.
Purity : >98% (HPLC)






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Biological Information
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Product NameMollugin
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NoteResearch use only, not for human use.
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Brief DescriptionMollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway.
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DescriptionMollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upregulation of the HO-1 and Nrf2 pathways and the downregulation of NF- κ B. Mollugin may be a novel therapeutic candidate for bone loss-associated disorders including osteoporosis, rheumatoid arthritis, and periodontitis. Also, it has anticancer efficacy, can modulate the HER2 pathway in HER2-overexpressing Y cells with a potential role in the treatment and prevention of human breast and ovarian Y with HER2 overexpression.
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In VitroMollugin (0-80 μM, 24 h) inhibits the expression of an NF-κB reporter gene induced by TNF-α in a dose-dependent manner.Mollugin (0-80 μM, 12 h) inhibits the proliferation of HeLa cells.Mollugin (0-80 μM, 12 h) inhibits TNF-α-induced phosphorylation and nuclear translocation of p65, phosphorylation and degradation of IκBα, and IKK phosphorylation, and inhibits the TNF-α-induced mRNA expression of Cyclin D1, c-Myc, and VEGF. Mollugin (0-80 μM, 12 h) enhances TNF-α-induced apoptosis. Cell Viability Assay Cell Line:HeLa, Hep3B, and HEK293 cells Concentration:0, 10, 20, 40, and 80 μM Incubation Time:24 h Result:Significantly inhibited NF-κB reporter gene expression in a dose-dependent manner, did not display significant cellular toxicity in HeLa, Hep3B, and HEK293 cells.Cell Proliferation Assay Cell Line:HeLa cells Concentration:0, 20, 40, and 80 μM Incubation Time:12 h Result:Inhibited the proliferation of HeLa cells. Apoptosis Analysis Cell Line:HeLa cellsConcentration:0, 10, 20, 40, and 80 μM Incubation Time:12 hResult:Slightly affected the caspase-3 activation, potentiated the effect of TNF-α-induced PARP cleavage, and enhanced the apoptotic effects of TNF-α.Western Blot Analysis Cell Line:HeLa cells Concentration:0, 10, 20, 40, and 80 μM Incubation Time:12 h Result:Significantly inhibited the TNF-α-induced p65 phosphorylation and block TNF-α-induced nuclear translocation of p65 in a dose-dependent manner, completely inhibited degradation of IκBα at 80 μM, and abolished the TNF-α-induced IKK phosphorylation at 80 μM. Inhibited the TNF-α-induced mRNA expression of Cyclin D1, c-Myc, and VEGF at 80 μM.
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In VivoMollugin (0-75 mg/kg, Orally, three times per week for 36 days) inhibits growth of HeLa cells in a xenograft tumor model. Animal Model:BALB/c female athymic nude mice (six-week-old, subcutaneously injected with 0.2 mL HeLa cells)Dosage:0, 25 and 75 mg/kg Administration:Orally, three times per week for 36 days Result:Suppressed tumor growth, whereas the body weight did not change. Significantly reduced the protein expression of p-p65 and COX-2 in the tumors.
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SynonymsRubimaillin | Mollugin
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorHER2| JAK2
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number55481-88-4
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Formula Weight284.3
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Molecular FormulaC17H16O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (117.23 mM)
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SMILESCC1(C=Cc2c(O1)c1ccccc1c(c2C(=O)OC)O)C
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Chemical Namemethyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang L, et al. Biochem Biophys Res Commun. 2014 Jul 18;450(1):247-54.
molnova catalog



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