Mirin

CAS No. 1198097-97-0

Mirin ( Mirin )

Catalog No. M10709 CAS No. 1198097-97-0

A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 45 In Stock
10MG 71 In Stock
25MG 129 In Stock
50MG 214 In Stock
100MG 394 In Stock
200MG 514 In Stock
500MG 825 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Mirin
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
  • Description
    A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity; prevents MRN-dependent activation of ATM (IC50=12 uM) without affecting ATM protein kinase activity; inhibits Mre11 nuclease activity at 100 uM, does not inhibit ExoIII nuclease activity; inhibits the G2 checkpoint, and blocks homology-directed repair (HDR) in mammalian cells.
  • Synonyms
    Mirin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MRN
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1198097-97-0
  • Formula Weight
    220.25
  • Molecular Formula
    C10H8N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    O=C1NC(S/C1=C\C2=CC=C(O)C=C2)=N
  • Chemical Name
    4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dupré A, et al. Nat Chem Biol. 2008 Feb;4(2):119-25.
2. Lee JH, et al. J Biol Chem. 2013 May 3;288(18):12840-51.
3. Rozier L, et al. Mol Cell. 2013 Mar 28;49(6):1097-107.
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