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Minalrestat
CAS No. 129688-50-2
Minalrestat( —— )
Catalog No. M34649 CAS No. 129688-50-2
Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 392 | Get Quote |
|
| 5MG | 610 | Get Quote |
|
| 10MG | 867 | Get Quote |
|
| 25MG | 1260 | Get Quote |
|
| 50MG | 1702 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMinalrestat
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NoteResearch use only, not for human use.
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Brief DescriptionMinalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
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DescriptionMinalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes.
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In VitroWestern Blot Analysis Cell Line:Primary cultured rat mesangial cells Concentration:100 μM Incubation Time:48 h Result:Increased accumulation of PKC-α and -β2.
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In VivoAnimal Model:Alloxan (40 mg/kg i.v.)-induced diabetic rats Dosage:10 mg/kg/day Administration:Oral gavage, for 30 days.Result:Restored the decreased microvascular reactivity.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetReductase
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RecptorReductase
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Research Area——
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Indication——
Chemical Information
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CAS Number129688-50-2
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Formula Weight449.2
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Molecular FormulaC19H11BrF2N2O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C2(C=3C(C(=O)N1CC4=C(F)C=C(Br)C=C4)=CC=C(F)C3)CC(=O)NC2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Akamine EH, et al. Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes. J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42. ?
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