Minalrestat

CAS No. 129688-50-2

Minalrestat( —— )

Catalog No. M34649 CAS No. 129688-50-2

Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 392 Get Quote
5MG 610 Get Quote
10MG 867 Get Quote
25MG 1260 Get Quote
50MG 1702 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Minalrestat
  • Note
    Research use only, not for human use.
  • Brief Description
    Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
  • Description
    Minalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes.
  • In Vitro
    Western Blot Analysis Cell Line:Primary cultured rat mesangial cells Concentration:100 μM Incubation Time:48 h Result:Increased accumulation of PKC-α and -β2.
  • In Vivo
    Animal Model:Alloxan (40 mg/kg i.v.)-induced diabetic rats Dosage:10 mg/kg/day Administration:Oral gavage, for 30 days.Result:Restored the decreased microvascular reactivity.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Reductase
  • Recptor
    Reductase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    129688-50-2
  • Formula Weight
    449.2
  • Molecular Formula
    C19H11BrF2N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C2(C=3C(C(=O)N1CC4=C(F)C=C(Br)C=C4)=CC=C(F)C3)CC(=O)NC2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Akamine EH, et al. Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes. J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42. ?
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