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Miglustat

CAS No. 72599-27-0

Miglustat( N-Butyldeoxynojirimycin | NB-DNJ | OGT918 )

Catalog No. M24736 CAS No. 72599-27-0

Miglustat is an alkylated product of imino sugar deoxynojirimycin.It?is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 125 In Stock
25MG 232 In Stock
50MG 385 In Stock
100MG 561 In Stock
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Biological Information

  • Product Name
    Miglustat
  • Note
    Research use only, not for human use.
  • Brief Description
    Miglustat is an alkylated product of imino sugar deoxynojirimycin.It?is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).
  • Description
    Miglustat is an alkylated product of imino sugar deoxynojirimycin.It?is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).
  • In Vitro
    ——
  • In Vivo
    Animal Model:NPC1?/? mice Dosage:0.2?mg/kg Administration:Oral administration; once Result:Was able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability.
  • Synonyms
    N-Butyldeoxynojirimycin | NB-DNJ | OGT918
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    72599-27-0
  • Formula Weight
    219.28
  • Molecular Formula
    C10H21NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    O[C@H]1[C@H](O)[C@@H](CO)N(CCCC)C[C@@H]1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Abian, O., et al., Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. Mol Pharm, 2011. 8(6): p. 2390-7.
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