Mifepristone ( RU-486 )

Catalog No. M16134 CAS No. 84371-65-3

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Product Name

Mifepristone
Note

Research use only, not for human use.
Brief Description

Mifepristone is a progestational and glucocorticoid hormone antagonist.
Description

Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome.
Synonyms

RU-486
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

PR; Glucocorticoid Receptor
Research Area

Endocrinology
Indication

——

CAS Number

84371-65-3
Formula Weight

429.60
Molecular Formula

C29H35NO2
Purity

>98%(HPLC)
Solubility

Ethanol: 19 mg/mL (44.22 mM); DMSO: 85 mg/mL (197.86 mM)
SMILES

O=C1CCC2=C3[C@@H](C4=CC=C(N(C)C)C=C4)C[C@]5(C)[C@@](C#CC)(O)CC[C@@]5([H])[C@]3([H])CCC2=C1
Chemical Name

(8S,11R,13S,14S,17S)-11-(4-(dimethylamino)phenyl)-17-hydroxy-13-methyl-17-(prop-1-yn-1-yl)-6,7,8,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

1.Jiang W, et al. Bioorg Med Chem, 2006, 14(19), 6726-6732.

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