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Metoprine

CAS No. 7761-45-7

Metoprine ( —— )

Catalog No. M22187 CAS No. 7761-45-7

Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 143 In Stock
50MG 237 In Stock
100MG 357 In Stock
500MG 822 In Stock
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Biological Information

  • Product Name
    Metoprine
  • Note
    Research use only, not for human use.
  • Brief Description
    Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain.
  • Description
    Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain.?Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT.?Consequently, this compound can be a candidate for a prototype of drugs for the treatment of METH overdose.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    histamine N-methyltransferase; antifolate
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    7761-45-7
  • Formula Weight
    269.13
  • Molecular Formula
    C11H10Cl2N4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1nc(N)nc(N)c1-c1ccc(Cl)c(Cl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Junichi Kitanaka, et al. Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose. Drug Target Insights. 2016 Mar 2;10:1-7.
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