Methotrexate ( Amethopterin; CL 14,377; EMT 25299; MTX; NSC 740; R 9985 )

Catalog No. M15186 CAS No. 59-05-2

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HNMR

HPLC

MSDS

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Product Name

Methotrexate
Note

Research use only, not for human use.
Brief Description

Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations.
Description

Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations, the anti-phlogistic action of which is due to increased adenosine release at inflamed sites. Studies have demonstrated that methotrexate polyglutamates are active inhibitors of several enzymatic reactions, including dihydrofolate reductase.
Synonyms

Amethopterin; CL 14,377; EMT 25299; MTX; NSC 740; R 9985
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

hDHFR
Research Area

Inflammation/Immunology
Indication

——

CAS Number

59-05-2
Formula Weight

454.44
Molecular Formula

C20H22N8O5
Purity

>98%(HPLC)
Solubility

DMSO: 90 mg/mL warmed (198.04 mM)
SMILES

CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical Name

——

1.Al-Rashood ST, et al. Bioorg Med Chem. 2006 Dec 15;14(24):8608-2

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