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MethADP

CAS No. 3768-14-7

MethADP( —— )

Catalog No. M33017 CAS No. 3768-14-7

MethADP (Adenosine 5'-(α,β-methylene)diphosphate) is a specific CD73 inhibitor that inhibits the enzyme ecto-5′-nucleotidase (ecto), which has been used in the study of neurological and cardiovascular diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MethADP
  • Note
    Research use only, not for human use.
  • Brief Description
    MethADP (Adenosine 5'-(α,β-methylene)diphosphate) is a specific CD73 inhibitor that inhibits the enzyme ecto-5′-nucleotidase (ecto), which has been used in the study of neurological and cardiovascular diseases.
  • Description
    MethADP is a specific CD73 inhibitor.
  • In Vitro
    MethADP (AMP-CP: 20 μM) causes a marked inhibition of adenosine formation (0.96±0.96 μM) compared to untreated controls (9.6±1.5 μM) in A498 and RT4 cells, and MethADP (100 μM) completely inhibits the adenosine formation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CD73
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    3768-14-7
  • Formula Weight
    425.23
  • Molecular Formula
    C11H17N5O9P2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(CP(=O)(O)O)(=O)O)[C@H]1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mohlin C, et al. Studies of the extracellular ATP-adenosine pathway in human urinary tract epithelial cells. Pharmacology. 2009;84(4):196-202.?
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