Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radicals. Aralosides have anti-inflammatory effect, they also can effectively prevent acute alcoholic liver injury.

L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.

DCAI is an inhibitor of nucleotide exchange and nucleotide release acting by binding to the pocket adjacent to the Ras-SOS interface.