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McN3716

CAS No. 69207-52-9

McN3716 ( Methyl palmoxirate; NSC359682 )

Catalog No. M21897 CAS No. 69207-52-9

McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    McN3716
  • Note
    Research use only, not for human use.
  • Brief Description
    McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor.
  • Description
    Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF1α, a byproduct of PGI2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle.
  • Synonyms
    Methyl palmoxirate; NSC359682
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Carnitine palmitoyltransferase I (CPT-1)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    69207-52-9
  • Formula Weight
    298.46
  • Molecular Formula
    C18H34O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1(CCCCCCCCCCCCCC)OC1)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen CT, et al. Inhibiting mitochondrial β-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain. J Cereb Blood Flow Metab. 2014 Mar;34(3):376-9.
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