Mc-Val-Cit-PABC-PNP( Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate )

Catalog No. M12291 CAS No. 159857-81-5

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HPLC

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Product Name

Mc-Val-Cit-PABC-PNP
Note

Research use only, not for human use.
Brief Description

A cathepsin cleavable ADC peptide linker.
Description

A cathepsin cleavable ADC peptide linker.
In Vitro

——
In Vivo

——
Synonyms

Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
Pathway

Antibody Drug Conjugates (ADC)
Target

ADCs Linker/Click Chemistry
Recptor

ADCsLinker|Others
Research Area

Other Indications
Indication

——

CAS Number

159857-81-5
Formula Weight

737.7562
Molecular Formula

C35H43N7O11
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 37 mg/mL
SMILES

CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCCCCN3C(=O)C=CC3=O
Chemical Name

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-

1. Dubowchik GM, et al. Bioconjug Chem. 2002 Jul-Aug;13(4):855-69. 2. Doronina SO, et al. Bioconjug Chem. 2008 Oct;19(10):1960-3.

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