PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).

Trimethylamine N-oxide dihydrate a product of the oxidation of trimethylamine is considered as a protein stabilizer that may serve to counteract urea the major osmolyte of sharks skates and rays.

CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.