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MZ1

CAS No. 1797406-69-9

MZ1( MZ-1 | MZ 1 )

Catalog No. M12715 CAS No. 1797406-69-9

MZ1 is a?PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MZ1
  • Note
    Research use only, not for human use.
  • Brief Description
    MZ1 is a?PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.
  • Description
    MZ1 is a?PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4; induces reversible, long-lasting, and unexpectedly selective removal of BRD4 over BRD2 and BRD3.
  • In Vitro
    Western Blot Analysis Cell Line:LS174t cells Concentration:0, 100, and 250 nM Incubation Time:24 hours Result:Led to complete degradation of BRD4 protein, whereas the expression of BRD4 mRNA was not reduced.
  • In Vivo
    ——
  • Synonyms
    MZ-1 | MZ 1
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1797406-69-9
  • Formula Weight
    1002.644
  • Molecular Formula
    C49H60ClN9O8S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 25 mg/mL 24.93 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C([C@H]1N(C([C@@H](NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)C(C)(C)C)=O)CCC1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
  • Chemical Name
    (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zengerle M, et al. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.
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