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MZ1
CAS No. 1797406-69-9
MZ1( MZ-1 | MZ 1 )
Catalog No. M12715 CAS No. 1797406-69-9
MZ1 is a?PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 147 | In Stock |
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| 10MG | 192 | In Stock |
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| 25MG | 293 | In Stock |
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| 50MG | 385 | In Stock |
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| 100MG | 561 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMZ1
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NoteResearch use only, not for human use.
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Brief DescriptionMZ1 is a?PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.
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DescriptionMZ1 is a?PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4; induces reversible, long-lasting, and unexpectedly selective removal of BRD4 over BRD2 and BRD3.
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In VitroWestern Blot Analysis Cell Line:LS174t cells Concentration:0, 100, and 250 nM Incubation Time:24 hours Result:Led to complete degradation of BRD4 protein, whereas the expression of BRD4 mRNA was not reduced.
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In Vivo——
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SynonymsMZ-1 | MZ 1
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number1797406-69-9
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Formula Weight1002.644
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Molecular FormulaC49H60ClN9O8S2
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Purity>98% (HPLC)
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SolubilityDMSO : 25 mg/mL 24.93 mM; H2O : < 0.1 mg/mL
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SMILESO=C([C@H]1N(C([C@@H](NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)C(C)(C)C)=O)CCC1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
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Chemical Name(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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TL13-12
TL13-12 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of TAE684 and the cereblon ligand pomalidomide.
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m-PEG24-NH2
m-PEG24-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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DBCO-S-S-PEG3-biotin
DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry.?The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label.?PEG Linkers can be used in the synthesis of PROTACs.
