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MYLS22

CAS No. 306959-01-3

MYLS22( —— )

Catalog No. M23118 CAS No. 306959-01-3

MYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 32 In Stock
5MG 51 In Stock
10MG 87 In Stock
25MG 149 In Stock
50MG 228 In Stock
100MG 352 In Stock
200MG 528 In Stock
500MG 836 In Stock
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Biological Information

  • Product Name
    MYLS22
  • Note
    Research use only, not for human use.
  • Brief Description
    MYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor.
  • Description
    MYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor. MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression.
  • In Vitro
    Western Blot Analysis Cell Line:MLE12 cells Concentration:10 nM Incubation Time:30 min Result:Increased the phosphorylation levels of RIPK3 and MLKL protein.
  • In Vivo
    Animal Model:LPS‐induced ALI miceDosage:12.5 mg/kg Administration:i.p., 2 days Result:Increased lung inflammatory score, Tnf‐α and pro‐Il‐1β mRNA expression, and total IL‐1β or IL‐1β p17 protein expression.Increased the levels of RIPK3, MLKL protein, and their phosphorylation.Decreased the levels of SPC protein.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    OPA1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    306959-01-3
  • Formula Weight
    443.52
  • Molecular Formula
    C??H??N?O?S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL (112.73 mM; ultrasonic and warming and heat to 60°C)
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stéphanie Herkenne, et al. Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metab. 2020 May 5;31(5):987-1003.e8.
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