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MV1

CAS No. 1001600-54-9

MV1( MV 1 )

Catalog No. M10018 CAS No. 1001600-54-9

A small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MV1
  • Note
    Research use only, not for human use.
  • Brief Description
    A small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.
  • Description
    A small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs; induces cell death that is dependent on TNF signaling and de novo protein biosynthesis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MV 1
  • Pathway
    Apoptosis
  • Target
    IAP
  • Recptor
    IAP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1001600-54-9
  • Formula Weight
    576.738
  • Molecular Formula
    C33H44N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL 216.74 mM
  • SMILES
    O=C(OC)C(NC([C@H]1N(C([C@H](C2CCCCC2)NC([C@@H](NC)C)=O)=O)CCC1)=O)C(C3=CC=CC=C3)C4=CC=CC=C4
  • Chemical Name
    methyl 2-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-3,3-diphenylpropanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Varfolomeev E, et al. Cell. 2007 Nov 16;131(4):669-81. 2. Shibata N, et al. J Med Chem. 2017 Jun 23. doi: 10.1021/acs.jmedchem.7b00168.
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  • MV1

    A small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.

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