MV1( MV 1 )

Catalog No. M10018 CAS No. 1001600-54-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MV1
Note

Research use only, not for human use.
Brief Description

A small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.
Description

A small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs; induces cell death that is dependent on TNF signaling and de novo protein biosynthesis.
In Vitro

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In Vivo

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Synonyms

MV 1
Pathway

Apoptosis
Target

IAP
Recptor

IAP
Research Area

——
Indication

——

CAS Number

1001600-54-9
Formula Weight

576.738
Molecular Formula

C33H44N4O5
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 125 mg/mL 216.74 mM
SMILES

O=C(OC)C(NC([C@H]1N(C([C@H](C2CCCCC2)NC([C@@H](NC)C)=O)=O)CCC1)=O)C(C3=CC=CC=C3)C4=CC=CC=C4
Chemical Name

methyl 2-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-3,3-diphenylpropanoate

1. Varfolomeev E, et al. Cell. 2007 Nov 16;131(4):669-81. 2. Shibata N, et al. J Med Chem. 2017 Jun 23. doi: 10.1021/acs.jmedchem.7b00168.

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