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MUT-056399

CAS No. 1269055-85-7

MUT-056399 ( FAB-001 )

Catalog No. M11129 CAS No. 1269055-85-7

A novel, highly potent inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MUT-056399
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel, highly potent inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli.
  • Description
    A novel, highly potent inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli; shows activity against S. aureus strains, including MSSA, MRSA, linezolid-resistant, and multidrug-resistant strains with MIC90s of 0.03-0.12 ug/ml; also has active against coagulase-negative staphylococci with MIC90s of 0.12-4 ug/ml; active in vivo (19.3-49.6 mg/kg/day).Bacterial Infection Preclinical
  • Synonyms
    FAB-001
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    1269055-85-7
  • Formula Weight
    293.27
  • Molecular Formula
    C15H13F2NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    CCC1=CC(=C(C=C1F)OC2=C(C=C(C=C2)C(=O)N)F)O
  • Chemical Name
    Benzamide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Escaich S, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7.
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