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MTK458
CAS No. 2499962-58-0
MTK458( —— )
Catalog No. M36457 CAS No. 2499962-58-0
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
|
| 5MG | 69 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMTK458
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NoteResearch use only, not for human use.
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Brief DescriptionMTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.
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DescriptionMTK458 is an orally active brain penetrant PINK1 activator. MTK458 binds to PINK1 and stabilizes an active heterocomplex, thereby increasing mitophagy. MTK458 can be used for research on Parkinson's disease.
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In Vitro——
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In VivoAnimal Model:Stratum of mice injected with α-synuclein preformed fibrils (PFFs) Dosage:50 mg/kg Administration:Oral gavage (p.o.), daily, 6 months Result:Rescued an activity deficit in freely moving PFF mice.Reduced the levels of inflammatory markers (TREM2, IL-6, and CXCL1).Animal Model:C57BL6J wildtype mice injected with PFF Dosage:50 mg/kg Administration:Oral gavage (p.o.); 7 days, 3 weeks Result:Decreased pUb in the brain and plasma of PFF seeded mice.
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Synonyms——
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PathwayOthers
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TargetPTEN
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RecptorPTEN
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Research Area——
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Indication——
Chemical Information
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CAS Number2499962-58-0
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Formula Weight332.32
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Molecular FormulaC17H15F3N4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (300.91 mM; Ultrasonic )
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SMILESN(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chin RM, et al. Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528378. ?
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MTK458
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.
