MSX-122

Research use only, not for human use.

MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).

MSX-122 is a n orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the GPCR (G protein-coupled receptor) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; it is also a co-receptor for HIV entry into T cells. The chemical structure of MSX-122 is very similar to that of WZ811.

MSX122; MSX 122; MSX-122

Membrane Transporter/Ion Channel

AMPK

CXCR4;CXCL12

Cancer

——

897657-95-3

292.34

C16H16N6

98%

DMSO : 4 mg/mL 13.68 mM;

C(Nc1ncccn1)c3ccc(CNc2ncccn2)cc3

N,N'-(1,4-phenylenebis(methylene))bis(pyrimidin-2-amine)

(-20℃)

With Ice Pack

≥ 2 years