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MSC2504877

CAS No. 1460286-21-8

MSC2504877 ( 3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one )

Catalog No. M28544 CAS No. 1460286-21-8

MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MSC2504877
  • Note
    Research use only, not for human use.
  • Brief Description
    MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb.
  • Description
    MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb.
  • Synonyms
    3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PTP1B
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1460286-21-8
  • Formula Weight
    282.3
  • Molecular Formula
    C17H18N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1NC(=CN2C1=CC=C2C)C=3C=CC(=CC3)C(O)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Steinhauer J, et al. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Mol Biol Cell. 2009 Dec;20(24):5224-35.
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