MSC2360844

Research use only, not for human use.

MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).

MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).(In Vitro):MSC2360844 inhibits B cell proliferation in a concentration-dependent manner with an IC50 of 48?nM. MSC2360844 blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells.(In Vivo):in a murine SLE model，MSC2360844 ameliorates disease manifestations .

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PI3K/Akt/mTOR signaling

PI3K

Apoptosis

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1305267-37-1

526.6

C26H27FN4O5S

>98% (HPLC)

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Fc1cccc2-c3c(CS(=O)(=O)c12)c(nn3-c1ccc(CN2CCOCC2)cc1)C(=O)N1CCOCC1

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(-20℃)

With Ice Pack

≥ 2 years